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Anti-Human CARMA1 - 0.1 mg

Anti-Human CARMA1 - 0.1 mg

Item no.	LEIN-C1217-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9. 2. Gaide, O. et al. (2001) FEBS Lett. 496:121-7. 3. Bertin, J. et al. (2001) J. Biol. Chem. 276:11877-82. 4. McAllister-Lucas, LM. et al. (2001) J. Biol. Chem. 276:30589-97.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	CARMA1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.1 CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.2, 3 Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I/K complex, thereby regulating activation of the NF-κB transcription factor.5 Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.6
Background	CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.¹ CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.^{2, 3} Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I/K complex, thereby regulating activation of the NF-κB transcription factor.⁵ Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.⁶
PubMed	CARMA1
Manufacturer - Specificity	Rabbit Anti-Human CARMA1 recognizes an epitope near the C-terminus of human and mouse CARMA1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828364
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:C1231
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, CARMA1, CARMA1, Human, Anti-Human CARMA1, CARMA1 Antibody, PPBL, BENTA, BIMP3, IMD11, CARMA1, Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1217-0.1mg-safety-datasheet.pdf