Anti-Human cIAP (CT) - 20 µg

Primary Monoclonal Antibodies>Apoptosis & Cell Biology

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Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.1 The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7.2, 3 The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor.2, 4 Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP.5 Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.6

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.