Anti-Human CNTF (Clone 21809) - 25 µg

ELISA Indirect, N, WB

CNTF

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Ciliary neurotrophic factor (CNTF) is a cytokine that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.1, 2 With these abilities, CNTF has implications for Parkinson's disease and cell-replacement therapies for other disorders.3 CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. The advantages and disadvantages of CNTF has shown promise as a therapeutic strategy to alleviate obesity-associated diseases.4

Neutralization: This antibody is useful for neutralization of Human CNTF bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human CNTF (at 400 ng/ml) is 2-6 µg/ml.

Mouse Anti-Human Ciliary Neurotrophic Factor (CNTF) (Clone 21809) recognizes an epitope on Human CNTF. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human CNTF (Accession # P26441.1)

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