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Anti-Human CXCL6 - 25 µg

Anti-Human CXCL6 - 25 µg

Item no.	LEIN-C1398-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	25 ug 500 ug
Category	Neuroscience Neural Signaling Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Applications	WB, ELISA
Clone	60910
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Van Damme, J. et al. (1993)Biochemistry 32: 10170 2. Van Damme, J. et al. (1997)Biochemistry 36: 2716 3. Linge, HM. et al. (2008)Antimicrobial Agents And Chemotherapy 52: 2599
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Cap, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	CXCL6
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.1, 2 It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.2 CXCL6 possesses antibacterial activity against Gram-positive and Gram-negative pathogenic bacteria of relevance to mucosal infections. CXCL6 causes membrane disruption in a dose-dependent manner. This is reduced in the presence of NaCl, which inhibits the binding of the peptide to the bacterial surface.3 CXCL6, in addition to its chemotactic and angiogenic properties, is likely to contribute to direct antibacterial activity during localized infection and thus plays a role in innate immunity.
Background	Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.^{1, 2} It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.² CXCL6 possesses antibacterial activity against Gram-positive and Gram-negative pathogenic bacteria of relevance to mucosal infections. CXCL6 causes membrane disruption in a dose-dependent manner. This is reduced in the presence of NaCl, which inhibits the binding of the peptide to the bacterial surface.³ CXCL6, in addition to its chemotactic and angiogenic properties, is likely to contribute to direct antibacterial activity during localized infection and thus plays a role in innate immunity.
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human CXCL6 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human CXCL6 (at 0.08 ng/ml) is 8-30 µg/ml.
PubMed	CXCL6
Manufacturer - Research Area	Chemokine
Manufacturer - Specificity	Mouse Anti-Human CXCL6 (Clone 60910) recognizes an epitope on Human CXCL6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. In sandwich ELISAs, less than 0.04% cross-reactivity was observed with rhNAP-2, rhGROα, rhGROβ, rhBLC, rhENA-78, rmCXCL6, rmMIP-2, rhIL-8, rhIP-10, rhMIG, rhSDF-1α and rhSDF-1β.
RRID	AB_2828455
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human CXCL6 (Accession # P80162)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CXCL6, GCP-2, SCYB6, CKA-3, 60910, Human, Anti-Human CXCL6, chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2), Chemokine alpha 3, CKA-3Granulocyte chemotactic protein 2, CXCL6, GCP-2, GCP2member 6 (granulocytechemotactic protein 2), GCP-2Small-inducible cytokine B6, Small inducible cytokine subfamily B (Cys-X-Cys), member b

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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LEIN-C1398-25ug-safety-datasheet.pdf