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Anti-Rat CNTF (Clone 34726) - 25 µg

Anti-Rat CNTF (Clone 34726) - 25 µg

Item no.	LEIN-C1441-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	25 ug 500 ug
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Regulation of Appetite Molecular Targets for Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	34726
Specific against	Rat (Rattus norvegicus)
Host	Mouse
Citations	1. Boschero, AC. et al. (2009) Cytokine 46(1):65-71 2. Thoenen, H. et al. (1994) J Neurobiol. 25: 1436 3. Hagg, T. et al. (2008) J Neurosci. 28: 2231 4. Febbraio, MA. et al. (2008) J Mol Med. 86: 353
NCBI	25707
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: To detect Rat CNTF this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for rrCNTF is approximately 5 ng/lane and 0.5 ng/lane under non-reducing and reducing conditions, respectively. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	CNTF
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Ciliary neurotrophic factor (CNTF) is a cytokine1 that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.2 With these abilities, CNTF has implications for Parkinson's disease and cell-replacement therapies for other disorders.3 CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. The advantages and disadvantages of CNTF has shown promise as a therapeutic strategy to alleviate obesity-associated diseases.4
Background	Ciliary neurotrophic factor (CNTF) is a cytokine¹ that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.² With these abilities, CNTF has implications for Parkinson's disease and cell-replacement therapies for other disorders.³ CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. The advantages and disadvantages of CNTF has shown promise as a therapeutic strategy to alleviate obesity-associated diseases.⁴
PubMed	CNTF
Manufacturer - Specificity	Mouse Anti-Rat Ciliary Neurotrophic Factor (CNTF) (Clone 34726) recognizes an epitope on Rat CNTF. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2828503
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	E. coli-Derived Recombinant Rat CNTF
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Ciliary Neurotrophic Factor, HCNTF, 34726, CNTF, Rat, Anti-Rat CNTF, ciliary neurotrophic factor, CNTF, HCNTF

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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LEIN-C1441-25ug-safety-datasheet.pdf