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Anti-Human CXCL11 (Clone 87328) - 500 µg

Anti-Human CXCL11 (Clone 87328) - 500 µg

Item no.	LEIN-C1448-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Quantity options	100 ug 25 ug 500 ug
Category	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Applications	WB, ELISA
Clone	87328
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Neote, K. et al. (1998) J Exp Med. 187: 2009 2. Losey, J. et al. (2007) Eur Neurol. 58: 228 3. Barr, ML. et al. (2007) Mol Cell Biochem. 296: 1
NCBI	6373
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Cap, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	CXCL11
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.1 CXCL11 recruits activated Th1 cells to sites of inflammation2 and is thought to play a critical role in allograft rejection.3 CXCL11 may also be involved in multiple sclerosis (MS) pathogenesis.2
Background	Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.¹ CXCL11 recruits activated Th1 cells to sites of inflammation² and is thought to play a critical role in allograft rejection.³ CXCL11 may also be involved in multiple sclerosis (MS) pathogenesis.²
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human CXCL11 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human CXCL11 (at 15 ng/ml) is 0.2 - 0.8 µg/ml.
PubMed	CXCL11
Manufacturer - Research Area	Chemokine
Manufacturer - Specificity	Mouse Anti-Human CXCL11 (Clone 87328) recognizes an epitope on Human CXCL11. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2828510
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human CXCL11 (Accession # O146255)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Chemokine (C-X-C Motif) Ligand 11 , H174, I-TAC, IP-9, IP9, MGC102770, SCYB11, SCYB9B, B-R1, 87328, CXCL11, Human, Anti-Human CXCL11, beta-R1, b-R1, chemokine (C-X-C motif) ligand 11, CXCL11, H174, H174IP9, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, IP-9member 11, ITAC, I-TAC, I-TACMGC102770, SCYB9B, small inducible cytokine subfamily B (Cys-X-Cys), member 9B, Small-inducible cytokine B11

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1448-500ug-safety-datasheet.pdf