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Anti-Human CCL28 (Clone 62705) - 500 µg

Anti-Human CCL28 (Clone 62705) - 500 µg

Item no.	LEIN-C1451-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Quantity options	25 ug 500 ug
Category	Neuroscience Neuroinflammation Antibodies Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	62705
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Kunkel, SL. et al. (2003) J Clin. Invest. 111: 1001 2. John, AE. et al. (2005) J. Pathol. 166(2): 345 3. Hieshima, GB. et al. (2003) J Immunol. 170: 1452 4. Butcher, EC. et al. (2004) J Exp. Med. 200: 805
NCBI	56477
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	CCL28
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	CCL28, also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.1, 2, 3 CCL28 is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.3 CCL28 is a key regulator of IgA antibody-secreting cells (ASCs) accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant.4
Background	CCL28, also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.^{1, 2, 3} CCL28 is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.³ CCL28 is a key regulator of IgA antibody-secreting cells (ASCs) accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant.⁴
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human CCL28 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human CCL28 (at 4 ng/ml) is 15 - 45 µg/ml.
PubMed	CCL28
Manufacturer - Research Area	Chemokine
Manufacturer - Specificity	Mouse Anti-Human CCL28 (Clone 62705) recognizes an epitope on Human CCL28. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2828514
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	E. coli - Derived Recombinant Human CCL28 (Accession # Q9NRJ3)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CCL28, SCYA28, MEC, CCK1, 62705, Human, Anti-Human CCL28, CCL28, chemokine (C-C motif) ligand 28, MEC, member 28, MGC71902, Protein CCK1, VIC

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1451-500ug-safety-datasheet.pdf