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Anti-Human ICAM-1 - DyLight® 488

Anti-Human ICAM-1 - DyLight® 488

Item no.	LEIN-C1655-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Quantity options	100 ug 200 ug 50 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	FC
Clone	15, 2
Specific against	Human (Homo sapiens)
Host	Mouse
NCBI	3383
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Category	Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	ICAM-1
Country of Origin	USA
Shipping Temperature	Next Day 2-8°C
Storage Conditions	This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
Background	ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
PubMed	ICAM-1
Excitation Laser	Blue Laser (493 nm)
Manufacturer - Research Area	Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cel
Manufacturer - Specificity	Clone 15.2 recognizes an epitope on human ICAM-1.
RRID	AB_2828711
Concentration	0.2 mg/ml
Formulation	This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Immunogen	Purified Recombinant Human ICAM-1 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1655-50ug-safety-datasheet.pdf