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Anti-Human ICAM-1 (Clone 15.2) - Biotin - 50 µg

Anti-Human ICAM-1 (Clone 15.2) - Biotin - 50 µg

Item no.	LEIN-C168-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Quantity options	100 ug 200 ug 50 ug
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	15, 2
Specific against	Human (Homo sapiens)
Host	Mouse
NCBI	3383
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	Inter-Cellular Adhesion Molecule 1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein1 and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines.2 ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.3
Background	Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein¹ and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines.² ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.³
PubMed	Inter-Cellular Adhesion Molecule 1
Manufacturer - Research Area	Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cell
Manufacturer - Specificity	Mouse Anti-Human CD54 (Clone 15.2) recognizes Human CD54. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Anti-Human CD54 (ICAM-1) recognizes the (Mr 85-115 kDa) intercellular adhesion molecule ICAM-1 which permits antigen-independent adhesion between lymphocytes and their targets. The LFA-1 binding site is located in domain 1 of ICAM-1.^{1, 2}
RRID	AB_2828738
Concentration	0.5 mg/ml
Formulation	This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	ICAM-1 is a membrane glycoprotein with a wide tissue distribution that includes vascular endothelium and many cells of the immune system. CD54 is weakly expressed on resting peripheral blood lymphocytes. Upon activation by mitogens, the CD54 antigen is strongly expressed on B-cells, T-cells, macrophages and granulocytes. CD54 is the receptor for rhinoviruses and malaria.1
Immunogen	Purified Recombinant Human ICAM-1 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Inter-Cellular Adhesion Molecule 1, BB2, CD54, P3.58, 15.2, ICAM-1, Human ICAM1, Anti-Human ICAM-1-Biotin, Clone 15.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C168-50ug-safety-datasheet.pdf