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Anti-Human Caspase-3 - DyLight® 650 - 200 µg

Anti-Human Caspase-3 - DyLight® 650 - 200 µg

Item no.	LEIN-C1772-200ug
Manufacturer	Leinco Technologies
Amount	200 ug
Quantity options	100 ug 200 ug 50 ug
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	C31.129
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811 2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964 3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320
NCBI	836
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Caspase-3
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1, 2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3
Background	Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.^{1, 2} Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.³ Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.³
PubMed	Caspase-3
Excitation Laser	Red Laser (652 nm)
Manufacturer - Specificity	Mouse Anti-Human Caspase-3 Active Subunit (p17) (CASP3) (Clone C31.129) recognizes an epitope on Human CASP3. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2828838
Concentration	0.2 mg/ml
Formulation	This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen	Purified Recombinant Human CASP3 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Caspase-3 Active Subunit (p17), C31.129, CASP3, Human, Anti-Human Caspase-3 Active Subunit (p17) - DyLight® 650

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1772-200ug-safety-datasheet.pdf