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Anti-Mouse CD127 (IL-7Rα) - FITC - 500 µg

Anti-Mouse CD127 (IL-7Rα) - FITC - 500 µg

Item no.	LEIN-C2224-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Quantity options	100 ug 500 ug
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	A7R34
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Fry TJ et al. (2005) J Immunol. 174: 6571 2. Murre C et al. (2002) Embo J. 21: 103
NCBI	16197
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Quality Tested by Leinco FC The suggested concentration for this A7R34 antibody for staining cells in flow cytometry is ≤ 1 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
Manufacturer - Category	Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	CD127
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	CD127 (IL7R-α) is a 60-90 kD type I cytokine receptor involved in the regulation of lymphopoiesis. The active receptor is an α/γ chain heterodimer. The common γ chain, which also associates with the IL-2 receptor, serves mainly to activate signal transduction via the IL7R complex. CD127 also interacts with the Thymic Stromal Lymphopoietin Receptor (TSLPR). CD127 determines signaling events via its association with cytoplasmic signaling molecules and has been reported to be a useful marker for identifying memory and effector T cells.
Background	CD127 (IL7R-α) is a 60-90 kD type I cytokine receptor involved in the regulation of lymphopoiesis. The active receptor is an α/γ chain heterodimer. The common γ chain, which also associates with the IL-2 receptor, serves mainly to activate signal transduction via the IL7R complex. CD127 also interacts with the Thymic Stromal Lymphopoietin Receptor (TSLPR). CD127 determines signaling events via its association with cytoplasmic signaling molecules and has been reported to be a useful marker for identifying memory and effector T cells.
PubMed	CD127
Excitation Laser	Blue Laser (490 nm)
Ligand/Receptor	IL-7
Manufacturer - Research Area	Immunology
Manufacturer - Specificity	Clone A7R34 recognizes an epitope on mouse CD127.
RRID	AB_2829310
Concentration	0.2 mg/ml
Formulation	This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	IL-7Rα is expressed on bone marrow lymphoid precursors, pro-B cells, monocytes/macrophages, NK-cells, naïve T cells, memory CD4+ and CD8+ T cells, intestinal colorectal and renal carcinoma cell lines, and keratinocytes.
Immunogen	Purified Recombinant Mouse CD127 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CD127, IL-7Rα, Interleukin-7 receptor alpha, IL-7Rα chain, A7R34, Mouse, FITC, Anti-Mouse CD127 - Fluroescein, Flow Cytometry, Immunology, thymocytes, IL-2, IL-4, IL-9, IL-13, IL-15

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C2224-500ug-safety-datasheet.pdf