Anti-Mouse CD278 (ICOS) - PE - 50 µg

Primary Monoclonal Antibodies>Immune Checkpoints|Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers

Next Day 2 - 8°C

CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

CD278

B7h/B7RP-1/GL-50

Clone 7E.17G9 recognizes an epitope on mouse CD278.

0.2 mg/ml

ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.