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Anti-Human CD28 - Purified in vivo PLATINUM™ Functional Grade - 5.0 mg

Anti-Human CD28 - Purified in vivo PLATINUM™ Functional Grade - 5.0 mg

Item no.	LEIN-C2880-5.0mg
Manufacturer	Leinco Technologies
Amount	5 mg
Quantity options	1 mg 100 mg 25 mg 5 mg 50 mg
Category	Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody Monoclonal
Applications	FC, IP, IHC
Clone	CD28.2
Specific against	Human (Homo sapiens)
Host	Mouse
Purity	>98% by SDS Page
NCBI	940
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Costim, FC, IHC FF, IP, PhenoCycler®
Manufacturer - Category	Primary Monoclonal Antibodies>Immune Checkpoints\|PhenoCycler®\|Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	CD28
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
Background	CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
Other Applications Reported In Literature	IP IHC FF Costim CODEX®
PubMed	CD28
Ligand/Receptor	CD80, CD86
Manufacturer - Research Area	Costimulatory Molecules, Immunology
Manufacturer - Specificity	Clone CD28.2 recognizes an epitope on human CD28.
RRID	AB_2893096
Concentration	≥ 2.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Antigen Distribution	CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.
Endotoxin Level	≤ 0.5 EU/mg as determined by the LAL method
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CD28, MGC138290, Tp44, CD28.2, Human, Anti-Human CD28 - Purified Low Endotoxin Functional Formulation, CD28 antigen (Tp44), CD28 antigen, CD28 molecule, CD28, MGC138290, T-cell-specific surface glycoprotein CD28, Tp44, anti CD28, Cluster of Differentiation 28, MGC138290, Tp44, 37407, CD28, Human, Anti-Human CD28, anti human CD28, T44

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C2880-5.0mg-safety-datasheet.pdf