Anti-Human CD16 [3G8] – Purified - 500 µg

B, CyTOF®, FC, IHC FF, IP

CD16

Next Day 2 - 8°C

CD16 antibody, 3G8, recognizes human CD16, also known as low-affinity IgG receptor III (FcγRIII). There are two distinct forms of CD16, CD16a (FcγRIIIa) and CD16b (FcγRIIIb). CD16a is a 50-65 kDa heterooligomeric polypeptide-anchored transmembrane protein expressed by NK cells, macrophages, and subsets of monocytes1. CD16b is a 48 kDa monomeric glycosylphosphatidylinositol (GPI)-anchored protein expressed on neutrophils1. Upon binding to the Fc portion of IgG or IgG-antigen complex, both CD16 isoforms induce signaling cascades resulting in multiple functions, including phagocytosis, cytokine release, proliferation, degranulation, and antibody dependent cell-mediated cytotoxicity (ADCC)2.

Low affinity IgG Fc receptor, phagocytosis, ADCC

CD16

Immunology, Innate Immunity

AB_2893580

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Human PMN cells

Monoclonal Antibody, CD16, FcγRIII, 3G8, Human CD19, Anti-Human CD16, Clone 3G8, CD16, CD16A, Fc fragment of IgG receptor IIIa, Fc gamma RIII, FCG3, FCGR3, FcgRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20