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Anti-Human DAD1 - 0.1 mg

Anti-Human DAD1 - 0.1 mg

Item no.	LEIN-D314-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Nakashima, T. et al. (1993) Mol. Cell Biol.13:6367-74. 2. Stellar, H. (1995) Science 267:1445-9. 3. Gilmore, R. and Kelleher, DJ. (1997) Proc. Natl. Acad. Sci. USA 94:4994-9. 4. Sanjay, A. et al. (1998) J. Biol. Chem. 273:26094-9.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	DAD1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death1, a process important for normal organism development and tissue homeostasis.2 DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity.3, 4 Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death.5, 6 Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas7, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Background	Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death¹, a process important for normal organism development and tissue homeostasis.² DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity.^{3, 4} Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death.^{5, 6} Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas⁷, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
PubMed	DAD1
Manufacturer - Specificity	Rabbit Anti-Human DAD1 recognizes an epitope near the C-terminus of human and mouse DAD1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2829918
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:D316
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	DAD1 Antibody, OST2, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Defender against cell death 1, Oligosaccharyl transferase subunit DAD1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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LEIN-D314-0.1mg-safety-datasheet.pdf