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Anti-Human DDX3 (Intermediate Domain)

Anti-Human DDX3 (Intermediate Domain)

Item no.	LEIN-D325-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Linder, P. et al. (1989) Nature 337:121 2. Park, S. H. et al. (1998) Cytogenet. Cell Genet. 81:178 3. Lahn, B. T. et al. (1997) Science 278:675 4. Abdelhaleem, M. (2005) Clin. Biochem. 38:499
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Infectious Diseases
Manufacturer - Targets	DDX3
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases.1, 2 DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome.3 DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation.4 It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.
Background	DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases.^{1, 2} DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome.³ DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation.⁴ It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.
PubMed	DDX3
Manufacturer - Specificity	Rabbit Anti-Human DDX3 recognizes an epitope in the intermediate domain of Human, Mouse and Rat DDX3. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2829920
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-D325-0.1mg-safety-datasheet.pdf