Anti-Mouse DCC - 100 µg

B, WB

DCC

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Deleted in Colorectal Carcinoma, also known as DCC is a tumor suppressor gene found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine.1 DCC may participate in signaling pathways that regulate cell proliferation and/or differentiation, two cellular processes that often go awry during tumorigenesis.2 DCC is required for the formation of major axonal projections by embryonic cortical neurons, including the corpus callosum, hippocampal commissure, and cortico-thalamic tracts.3

Blocking: Approximately 10 - 20 μg/mL of the antibody will block 50% of the binding of 50 ng/mL of rcNetrin-2 to immobilized rmDCC/Fc chimera (100 μL of a 2 μg/mL solution was coated in each well) in a functional ELISA assay.

Goat Anti-Mouse Deleted in Colorectal Cancer (DCC) recognizes Mouse DCC. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

Sf 21-Derived Recombinant Mouse DCC Extracellular Domain

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