Anti-Human FLASH (CT) - 20 µg

Primary Monoclonal Antibodies>Apoptosis & Cell Biology

Next Day Ambient

A novel mammalian CED-4 homologous was recently identified and cloned in mouse1 and human2 and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.1 There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.1, 2 FLASH is widely expressed.

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Polyclonal Antibody, FLICE-Associated Huge Protein, FLICE Associated Huge Protein, FLASH, Human, Anti-Human FLASH (CT), FLASH Antibody, CED-4, FLASH, RIP25, KIAA1315, CASP8-associated protein 2, FLICE-associated huge protein