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Anti-Influenza A, Nucleocapsid (Clone 1078) - Purified No Carrier Protein

Anti-Influenza A, Nucleocapsid (Clone 1078) - Purified No Carrier Protein

Item no.	LEIN-F610-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Quantity options	100 ug 500 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Applications	ELISA
Clone	1078
Specific against	Influenza A Virus (H9 Subtype)
Purity	≥95% monomer by analytical SEC
Citations	1. Types of Influenza viruses (2019) Center for Disease Control and Prevention. 2. Hu Y, Sneyd H, et al. (2017) Curr Top med Chem. 2017; 17(20): 2271–2285. 3. Portela A, Digard P. (2012) J. Gen Virol. 2002 Apr;83(Pt 4):723-734. 4. Sherry L, Smith M, et al. (2014) Journal of Virology. 2014; 88(21); 12326-12338. DOI https://doi.org/10.1128/JVI.01542-14
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Specificity	Influenza A Virus
Manufacturer - Applications	Quality Tested by Leinco ELISA
Manufacturer - Category	Primary Monoclonal Antibodies>Infectious Diseases\|Recombinant Antibodies
Manufacturer - Targets	Influenza A Nucleocapsid
Country of Origin	USA
Shipping Temperature	Ships Overnight on Blue Ice
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	There are four types of Influenza (flu) viruses: type A, B, C, and D. Influenza A and B viruses are routinely spread in people and other mammals, while also known for seasonal flu epidemics each year. Influenza A is the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. Influenza A is classified into two main protein subtypes, hemagglutinin (HA) and neuraminidase (NA), located on the surface of the virus. Breaking down the proteins further, there are 18 hemagglutinin subtypes and 11 different neuraminidase subtypes1. Influenza A can be even further classified into specific clades (also known as groups) and sub-clades (also known as sub-groups) based on similarity of their HA/NA gene sequences1. The Nucleocapsid protein or nucleoprotein (NP) of the influenza virus A negative-strand RNA’s primary function is to encapsulate the virus genome for the purpose of RNA transcription, replication and packaging2. Specifically, NP is the most abundant viral protein in infected cells2, therefore the NP can be and has been used for anti-influenza drug development3 The NP of influenza A and B viruses share up to 38% of their amino acid sequence, indicating region functionality differences at the amino acid level4
Background	There are four types of Influenza (flu) viruses: type A, B, C, and D. Influenza A and B viruses are routinely spread in people and other mammals, while also known for seasonal flu epidemics each year. Influenza A is the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. Influenza A is classified into two main protein subtypes, hemagglutinin (HA) and neuraminidase (NA), located on the surface of the virus. Breaking down the proteins further, there are 18 hemagglutinin subtypes and 11 different neuraminidase subtypes¹. Influenza A can be even further classified into specific clades (also known as groups) and sub-clades (also known as sub-groups) based on similarity of their HA/NA gene sequences¹. The Nucleocapsid protein or nucleoprotein (NP) of the influenza virus A negative-strand RNA’s primary function is to encapsulate the virus genome for the purpose of RNA transcription, replication and packaging². Specifically, NP is the most abundant viral protein in infected cells², therefore the NP can be and has been used for anti-influenza drug development³ The NP of influenza A and B viruses share up to 38% of their amino acid sequence, indicating region functionality differences at the amino acid level⁴
PubMed	Influenza A Nucleocapsid
Manufacturer - Research Area	Infectious Disease
Manufacturer - Expression host	HEK-293
Manufacturer - Specificity	Anti-Influenza A, Nucleocapsid (Clone 1078) specifically targets an epitope on the Influenza A Nucleocapsid Protein
RRID	AB_2893599
Concentration	≥1.0 mg/ml
Formulation	This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution	The nucleocapsid protein is expressed in the internal nucleocapsid of Influenza A
Immunogen	Sequenced from human patients
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-F610-500ug-safety-datasheet.pdf