Anti-Human HGF - 25 µg

IHC, N, WB

HGF

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Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.1Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.

Neutralization: This antibody is useful for neutralization of Human HGF bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human HGF (at 100 ng/ml) is 0.1 - 0.3 µg/ml.
Immunohistochemistry: Suitable for use at concentration of 8-25 µg/mL.

Other Molecules

AB_2830320

< 0.1 EU/µg as determined by the LAL method

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.