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Anti-Mouse/Human IL-5 - APC

Anti-Mouse/Human IL-5 - APC

Item no.	LEIN-I-1063-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	FC, ICC
Clone	TRFK5
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
NCBI	16191 3567
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Quality Tested by Leinco Flow Cytometry:This antibody can be used at a concentration of ≤ 0.5 µg per 100 µl of whole blood (or per 1.0 x 10⁶ cells in a 100 µl total staining volume). Each lot of this antibody is quality control tested.
Manufacturer - Category	Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	IL-5
Country of Origin	USA
Shipping Temperature	Next Day 2-8°C
Storage Conditions	This APC conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.
Background	IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.
Function	Growth/differentiation of B cells, eosinophils; proliferation/cell activation/differentiation of eosinophilic granulocytes
Other Applications Reported In Literature	Additional reported applications (for the relevant formats) include: ELISA Neutralization Western Blotting IHC-FFPE IHC-FF
PubMed	IL-5
Excitation Laser	Red Laser (633 nm)
Manufacturer - Specificity	Clone TRFK5 recognizes mouse/human IL-5.
RRID	AB_2830396
Concentration	0.2 mg/ml
Formulation	This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation	The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-1063-100ug-safety-datasheet.pdf