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Anti-Human IkappaB Kinase Alpha (CT-3) (IKKalpha)

Anti-Human IkappaB Kinase Alpha (CT-3) (IKKalpha)

Item no.	LEIN-I-301-0.5mg
Manufacturer	Leinco Technologies
Amount	0.5 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. DiDonato, JA. et al. (1997) Nature 388:548 2. Regnier, CH. et al. (1997) Cell 90:373 3. Zandi, E. et al. (1997) Cell 91:243 4. Woronicz, JD. et al. (1997) Science 278:866
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	IκB Kinase Alpha
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories.1-4 IKK is a serine protein kinase, and the IKK complex contains α and β subunits (IKKα and IKKΒ). IKKα and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IκB-α. IKKα is expressed in a variety of human tissues.
Background	Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories.^1-4 IKK is a serine protein kinase, and the IKK complex contains α and β subunits (IKKα and IKKΒ). IKKα and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IκB-α. IKKα is expressed in a variety of human tissues.
PubMed	IκB Kinase Alpha
Manufacturer - Specificity	Rabbit Anti-Human IκB Kinase Alpha (IKKα) recognizes an epitope near the C-terminus of Human IKKα. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2830622
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:I-315
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-301-0.5mg-safety-datasheet.pdf