Anti-Mouse IGF-I - 25 µg

IHC FFPE, N, WB

IGF-1

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Insulin-like growth factor 1 (IGF-1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production of IGF-1is stimulated by growth hormone. Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis. IGF-1 is closely related to a second protein called IGF-2. IGF-1 is used by physicians as a screening test for growth hormone deficiency and excess. The IGF signaling pathway appears to play a crucial role in cancer. Several studies have shown that increased levels of IGF lead to an increased risk of cancer.1

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Neutralization: This antibody is useful for neutralization of Mouse IGF-1 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IGF-1 (at 15 ng/ml) is 0.2 – 1.0 µg/ml.

Goat Anti-Mouse Insulin Like Growth Factor-I (IGF-1) recognizes Mouse IGF-1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

E. coli-Derived Recombinant Mouse IGF-I

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