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Anti-Human IL-17E - 100 µg

Anti-Human IL-17E - 100 µg

Item no.	LEIN-I-410-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Gurney, AL. et al. (2001) J Biol Chem. 276:1660 2. Gurney, AL. et al. (2001) J Immunol. 167:6559 3. Hamid, Q. et al. (2006) J Allergy Clin. Immunol. 117:590
NCBI	64806
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	IL-17E
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin (IL)-17E, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL17B is also a ligand for the cytokine receptor IL17BR. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3
Background	Interleukin (IL)-17E, is a novel member of the IL-17 family of cytokines¹ and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.² IL17B is also a ligand for the cytokine receptor IL17BR. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8. ¹ IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.³
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of IL‑17E/IL‑25-induced CXCL1/GRO alpha secretion in the HT‑29 human colon adenocarcinoma cell line. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-22 (at 1 ng/ml) is 0.5 - 2.5 µg/ml.
PubMed	IL-17E
Manufacturer - Specificity	Rabbit Anti-Human Interleukin 17E (IL-17E) recognizes Human IL-17E. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830672
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human IL-17E (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Interleukin-17E, IL25, IL-17E, Human IL-17E, Anti-Human IL-17E, IL17E, IL-17E, IL17Einterleukin-17E, IL25, IL-25, interleukin 17E, interleukin 25, Interleukin-17E, interleukin-25

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-410-100ug-safety-datasheet.pdf