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Anti-Human CD119 (IFN-γ Rα Chain) - 25 µg

Anti-Human CD119 (IFN-γ Rα Chain) - 25 µg

Item no.	LEIN-I-600-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	Caprine
Citations	1. Calderon, J. et al. (1988) PNAS 85:4837 2. Garcia-Sastre, A. et al. (2002) Int. Rev. Immunol. 21:305 3. Fish, E. et al. (2002) J. Interferon Cytokine Res. 22:835
NCBI	15979
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Indirect, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	IFNγ Rα
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
Background	IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
Other Applications Reported In Literature	N This antibody is useful for neutralization of Mouse IFN-γ RI bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IFN-γ RI (at 1.0 ng/ml) is 0.2-1.0 µg/ml.
PubMed	IFNγ Rα
Manufacturer - Specificity	Goat Anti-Mouse IFN-γ RI recognizes Mouse IFN-γ RI. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830723
Antigen Distribution	The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	NS0-Derived Mouse IFN-γ R1 Extracellular Domain
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Interferon Gamma Receptor 1, CD119, IFN-γR, IFN-γRα, IFN-α R1, CDw119, IFNGR1, Mouse IFN-γ R1, Anti-Mouse IFN-γ R1, AVP, type 2, CD119 antigen, CD119, FLJ45734, IFN-gamma R1, IFN-gamma receptor 1, IFNgammaR1, IFN-gamma-R1, IFNGR, IFNGR1, IFN-gR1, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain, type 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-600-25ug-safety-datasheet.pdf