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Anti-Human ICOS - 100 µg

Anti-Human ICOS - 100 µg

Item no.	LEIN-I-611-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug
Category	Oncology Antibodies By Cell Type Hematology Lymphoma Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Flavell, RA. et al. (2001) Nature 409: 97 2. Bachmann, MF. et al. (2000) J Exp Med. 192: 53 3. Kroczek, RA. et al. (1999) Nature 397: 263
NCBI	29851
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines\|Primary Monoclonal Antibodies>Immune Checkpoints
Manufacturer - Targets	ICOS
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Inducible co-stimulator (ICOS) is an inducible homodimeric costimulator protein that is structurally and functionally related to CD28. It is a third member of the CD28/CTLA4 family and it is expressed on activated T cells.1ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses.2 ICOS is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.3
Background	Inducible co-stimulator (ICOS) is an inducible homodimeric costimulator protein that is structurally and functionally related to CD28. It is a third member of the CD28/CTLA4 family and it is expressed on activated T cells.¹ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses.² ICOS is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.³
Other Applications Reported In Literature	IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 5-15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
PubMed	ICOS
Manufacturer - Specificity	Goat Anti-Human Inducible Costimulator (ICOS) recognizes Human ICOS. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830733
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human ICOS (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Inducible Co-Stimulator, AILIM, ICOS, Human ICOS, Anti-Human ICOS, Activation-inducible lymphocyte immunomediatory molecule, AILIM, AILIMCD278, CD278 antigen, CD278, CRP-1, CVID1, ICOS, inducible costimulator, inducible T-cell costimulator, inducible T-cell co-stimulator, MGC39850

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-611-100ug-safety-datasheet.pdf