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Anti-Mouse IL-11 Rα - 25 µg

Anti-Mouse IL-11 Rα - 25 µg

Item no.	LEIN-I-656-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB
Specific against	Mouse (Murine, Mus musculus)
Host	Caprine
Citations	1. Begley, CG. et al. (1997) Blood 90: 2148 2. Pasqualini, R. et al. (2009) Cancer Res. 69: 1995
NCBI	16157
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	IL-11 R alpha
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin 11 receptor alpha (IL11RA) is a subunit of the interleukin 11 receptor that is expressed in hematopoietic and other organs.1 IL11RA is a functional target in bone metastasis and is considered as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor.2/sup>
Background	Interleukin 11 receptor alpha (IL11RA) is a subunit of the interleukin 11 receptor that is expressed in hematopoietic and other organs.¹ IL11RA is a functional target in bone metastasis and is considered as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor.^2/sup>
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Mouse IL-11 Rα bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IL-11 Rα (at 0.3 ng/ml) is 2-6 µg/ml.
PubMed	IL-11 R alpha
Manufacturer - Specificity	Goat Anti-Mouse Interleukin-11 Receptor Alpha (IL-11 Rα) recognizes Mouse IL-11 Rα. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830778
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 10 ng/mg as determined by the LAL method
Immunogen	NS0 - derived mouse IL-11 Rα
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Interleukin-11 Receptor Alpha, IL11RA, MGC2146, IL-11 Rα, Mouse IL-11 Rα, Anti-Mouse IL-11 Rα, AI314697, GP130, IL-11 R alpha, IL11R alpha, IL11RA; IL-11Ra, Il11ra2, NR1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-656-25ug-safety-datasheet.pdf