Anti-Mouse IFN-γ - 500 µg

CyTOF®, FC, N, WB

IFNγ

Next Day Ambient

Mouse IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma species-specific and is biologically active only in human and primate cells.

N This antibody is useful for neutralization of Mouse IFN-γ bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IFN-γ (at 2.5 ng/ml) is 0.075 - 0.3 µg/ml.
CyTOF® Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Other Molecules

AB_2830790

< 0.1 EU/µg as determined by the LAL method

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.