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Anti-Rat IL-1 Rrp2 - 25 µg

Anti-Rat IL-1 Rrp2 - 25 µg

Item no.	LEIN-I-680-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	25 ug 500 ug
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	131011
Specific against	Rat (Rattus norvegicus)
Host	Mouse
Citations	1. Sims, JE. et al. (2004) J Biol Chem. 279: 13677 2. Taylor, JJ. et al. (2007) Clin Exp Immunol. 147: 217
NCBI	171106
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: To detect Rat IL-1 Rrp2 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Rat IL-1 Rrp2 is 25 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IL-1 Rrp2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin-1 receptor related protein 2 (IL-1 Rrp2) is a receptor for IL-1F6 which is a proinflammatory member of IL-1 family. IL-1F8, and IL-1F9 also signal through IL-1Rrp2 and IL-1RAcP.1 IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defense in the skin and the gastrointestinal (GI) tract including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8, indicating a possible role in rheumatoid arthritis (RA).2
Background	Interleukin-1 receptor related protein 2 (IL-1 Rrp2) is a receptor for IL-1F6 which is a proinflammatory member of IL-1 family. IL-1F8, and IL-1F9 also signal through IL-1Rrp2 and IL-1RAcP.¹ IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defense in the skin and the gastrointestinal (GI) tract including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8, indicating a possible role in rheumatoid arthritis (RA).²
PubMed	IL-1 Rrp2
Manufacturer - Specificity	Mouse Anti-Rat Interlekin-1 Receptor rp2 (IL-1 Rrp2) (Clone 131011) recognizes an epitope on Rat IL-1 Rrp2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows 100% cross-reactivity rhIL-1 Rrp2 and no cross-reactivity with rmIL-1 RI, rmIL-1 RII, rhIL-1 RAcP, rmIL-1 R5, rmIL-1 R7 or rmIL-1 RAPL1.
RRID	AB_2830801
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Immunogen	NS0-Derived Recombinant Rat Interleukin-1 Receptor rp2
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin 1 Receptor Related Protein 2, IL-1 R6, 131011, IL-1 Rrp2, Rat, Anti-Rat IL-1 Rrp2, IL-1 R6, IL-1 Rrp2, IL1RL2, IL-1RL2, IL1Rrp2, IL-1Rrp2, IL1RRP2IL1R-rp2Interleukin-1 receptor-related protein 2, interleukin 1 receptor-like 2, interleukin-1 receptor-like 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-680-25ug-safety-datasheet.pdf