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Anti-Human IFN-γ Rα Chain (CD119) - 25 µg

Anti-Human IFN-γ Rα Chain (CD119) - 25 µg

Item no.	LEIN-I-691-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	25 ug 500 ug
Category	Antibodies Flow Cytometry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Applications	WB, FC, ELISA
Clone	92101
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Calderon, J. et al. (1988) PNAS 85: 4837 2. Garcia-Sastre, A. et al. (2002) Int. Rev. Immunol. 21: 305 3. Fish, E. et al. (2002) J. Interferon Cytokine Res. 22: 835
NCBI	3459
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Indirect, FC, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IFNγ Rα
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
Background	IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human IFN-γ R1 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IFN-γ R1 (at 2 ng/ml) is 0.01 - 0.03 µg/ml. CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
PubMed	IFNγ Rα
Manufacturer - Specificity	Mouse Anti-Human Interferon Gamma Receptor 1 (IFN-γ R1) (Clone 92101) recognizes an epitope on Human IFN-γ R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2830812
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Antigen Distribution	The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Immunogen	NS0-Derived Recombinant Human IFN-γ Receptor 1 (Accession # P15260.1)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interferon Gamma Receptor 1, CD119, IFN-γR, IFN-γRα, IFN-α R1, CDw119, 92101, IFN-γ R1, Human, Anti-Human IFN-γ R1, AVP, type 2, CD119 antigen, CD119, FLJ45734, IFN-gamma R1, IFN-gamma receptor 1, IFNgammaR1, IFN-gamma-R1, IFNGR, IFNGR1, IFN-gR1, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain, type 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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LEIN-I-691-25ug-safety-datasheet.pdf