Anti-Human Lysosome Associated Membrane Protein-1 (LAMP-1) - 0.1 mg

IHC FF, IHC FFPE, WB

LAMP-1

Next Day Ambient

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components1, 2 and is negatively regulated by TOR (Target of rapamycin).3 A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome.4 LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, suggesting that each protein possesses some unique and necessary functions.

LAMP-1

AB_2831134

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.