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Anti-Human M-CSF R - 100 µg

Anti-Human M-CSF R - 100 µg

Item no.	LEIN-M1264-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug
Category	Antibodies Flow Cytometry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, FC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Stanley, ER. et al. (1978) Nature 274: 168 2. Byrne, PV. et al. (1981) J. Cell. Biol. 91: 848 3. Bourette, RP. et al. (2000) Growth Factors 17: 155 4. Stanley, ER. et al. (1996) Bone 18: 355 5. Novak, U. et al. (1996) Oncogene 13: 2607 6. Teitelbaum, SL. et al. (2005) J Clin Invest. 115(12):3418-27.
NCBI	1436
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	CyTOF®, FC, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	M-CSF R
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.1, 2, 3 It also triggers growth and development of mononuclear phagocytes and placental trophoblasts.4 M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues5 M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.6
Background	Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.^{1, 2, 3} It also triggers growth and development of mononuclear phagocytes and placental trophoblasts.⁴ M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues⁵ M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.⁶
Other Applications Reported In Literature	CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
PubMed	M-CSF R
Manufacturer - Research Area	Other Molecules
Manufacturer - Specificity	Goat Anti-Human Macrophage Colony Stimulating Factor Receptor (M-CSF R) recognizes Human M-CSF R. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831257
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human M-CSF R (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, M-CSF R, CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSF R, Human M-CSF R, Anti-Human M-CSF R, CD115 antigen, CD115, c-fms, colony stimulating factor 1 receptor, CSF1R, CSF-1-R, CSFR, EC 2.7.10.1, FMS proto-oncogene, FMSFIM2, macrophage colony stimulating factor I receptor, macrophage colony-stimulating factor 1 receptor, McDonough feline sarcoma viral v-fms oncogene homolog, M-CSF R, MCSFR, M-CSFR, Proto-oncogene c-Fms

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-M1264-100ug-safety-datasheet.pdf