Anti-Human MIP-1β (Clone 24006) - 100 µg

CyTOF®, ELISA Cap, FC, N, WB

MIP-1 beta

Next Day Ambient

Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.

Neutralization: This antibody is useful for neutralization of Human MIP-1β bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human MIP-1β (at 0.04 ng/ml) is 0.3 - 1.2 µg/ml.
CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Mouse Anti-Human MIP-1β/CCL4 (Clone 24006) recognizes an epitope on Human MIP-1β/CCL4. In Western blots, this antibody shows less than 4% cross­reactivity with recombinant human (rh) CCL3/MIP­1α and does not cross­react with recombinant mouse (rm) CCL3/MIP­1α or rmCCL4/MIP­1β. This monoclonal antibody was purified using affinity chromatography methods

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human MIP-1β (Accession # P13236)

Monoclonal Antibody, MIP-1β, CCL4, ACT2, AT744.1, G-26, LAG1, MGC104418, MGC126025, MGC126026, MIP1B1, SCYA2, SCYA4, 24006, MIP-1β, Human, Anti-Human MIP-1β, ACT2, ACT-2, AT744.1, C-C motif chemokine 4, CCL4, chemokine (C-C motif) ligand 4, Exodus-3, G-26 T-lymphocyte-secreted protein, G-26, HC21, LAG1, LAG-1, Lymphocyte activation gene 1 protein, Macrophage inflammatory protein 1-beta, MIP1 beta, MIP-1 beta, MIP1B, MIP1B1, MIP-1-beta, MIP-1-beta(1-69), PAT 744, Protein H400, SCYA2, SCYA4, secreted protein G-26, SIS-gamma, small inducible cytokine A4 (homologous to mouse Mip-1b), Small-inducible cytokine A4, T-cell activation protein 2