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Anti-Mouse M-CSF (Clone 131621) - 100 µg

Anti-Mouse M-CSF (Clone 131621) - 100 µg

Item no.	LEIN-M1276-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug 500 ug
Category	Antibodies ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Applications	ELISA
Clone	131621
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Nemunaitis, J. et al. (1998) Clin. Infect. Dis. 26: 1279 2. Ko, JS. et al. (2002) Exp Mol Med 34: 340
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Cap, N
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	M-CSF
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis, and secondary cytokine production in monocytes and macrophages.1 It binds to the Colony stimulating factor 1 receptor. M-CSF is known as one of the factors essential for osteoclast development.2
Background	Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis, and secondary cytokine production in monocytes and macrophages.¹ It binds to the Colony stimulating factor 1 receptor. M-CSF is known as one of the factors essential for osteoclast development.²
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Mouse M-CSF bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse M-CSF (at 2.5 ng/ml) is 4 - 16 µg/ml.
PubMed	M-CSF
Manufacturer - Research Area	Other Molecules
Manufacturer - Specificity	Rat Anti-Mouse macrophage colony stimulating factor (M-CSF) (Clone 131621) recognizes an epitope on Mouse M-CSF. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2831270
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Mouse M-CSF (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, M-CSF, CSF-1, MGI-IM, MGC31930, 131621, M-CSF, Mouse, Anti-Mouse M-CSF, colony stimulating factor 1 (macrophage), CSF1, CSF-1, Lanimostim, macrophage colony stimulating factor, macrophage colony-stimulating factor 1, MCSF, M-CSF, MCSFlanimostim, MGC31930

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-M1276-100ug-safety-datasheet.pdf