Anti-Rat MAG (Clone 118423) - 500 µg

N, WB

MAG

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Myelin-associated glycoprotein (MAG) is a transmembrane proteins that is a component of myelin in the central and peripheral nervous system.1 It promotes neurite outgrowth during the embryonic development, but inhibits axonal regeneration in the adult nervous system.2 MAG mediates cell-cell interactions between myelinating glial cells and neurons.3 MAG as an important component of the myelin-derived inhibition of nerve regeneration. The acute loss of MAG function can promote significant axon growth across a site of CNS nerve damage.4

Neutralization: This antibody is useful for neutralization of Rat MAG bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Rat MAG is 40 µg/ml.

Mouse Anti-Rat Myelin-Associated Glycoprotein (MAG) (Clone 118423) recognizes an epitope on Rat MAG. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

NS0-Derived Recombinant Rat MAG Extracellular Domain

Monoclonal Antibody, MAG, Siglec-4a, GMA, 118423, MAG, Rat, Anti-Rat MAG, GMAsialic acid binding Ig-like lectin 4A, MAG, myelin associated glycoprotein, myelin-associated glycoprotein, sialic acid-binding immunoglobulin-like lectin 4A, Siglec4a, Siglec-4a, S-MAG