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Anti-Human Nanog - Biotin - 50 µg

Anti-Human Nanog - Biotin - 50 µg

Item no.	LEIN-N144-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Primary
Applications	WB, ICC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Schöler, HR.et al. (2003) Cell 113:551 2. Pei, D. et al. (2005) J Biol. Chem. 280:1401 3. Rajpert-De Meyts, E. et al. (2005) Histopathology 47:48 4. Ligon, KL. et al. (2006) Am J Surg Pathol. 30:1613
NCBI	79923
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blot: Suitable for use at concentration of 0.1 µg/mL.
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	Nanog
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Nanog, a homeobox transcription factor1, plays a key role in maintaining stem cell pluripotency by regulating the expression of genes critical to stem cell renewal and differentiation.2 In other words, these cells have the ability to become virtually any cell of any of the three germ layers (endoderm, ectoderm, mesoderm). Nanog may be useful in the immunohistochemical diagnosis of tumors. It is expressed in germ cells of the fetus and in some germ cell tumors of the gonads3 and central nervous system.4
Background	Nanog, a homeobox transcription factor¹, plays a key role in maintaining stem cell pluripotency by regulating the expression of genes critical to stem cell renewal and differentiation.² In other words, these cells have the ability to become virtually any cell of any of the three germ layers (endoderm, ectoderm, mesoderm). Nanog may be useful in the immunohistochemical diagnosis of tumors. It is expressed in germ cells of the fetus and in some germ cell tumors of the gonads³ and central nervous system.⁴
Other Applications Reported In Literature	Immunocytochemistry: Suitable for use at concentration of5-15 µg/mL.
PubMed	Nanog
Manufacturer - Specificity	Goat Anti-Human Nanog recognizes Human Nanog. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831405
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human Nanog (Accession # ABZ92376)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Nanog, Human Nanog, Anti-Human Nanog-Biotin, FLJ12581, FLJ40451, hNanog, homeobox protein NANOG, Homeobox transcription factor Nanog, homeobox transcription factor Nanog-delta 48, Nanog homeobox, Nanog

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-N144-50ug-safety-datasheet.pdf