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Recombinant human HIF-1 alpha/HIF1A protein

Recombinant human HIF-1 alpha/HIF1A protein

Item no.	NKM-HIF0501-500ug
Manufacturer	NKMAX
Amount	500 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 90% by SDS-PAGE
Sequence	MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KS
Citations	Okuyama H. et al., (2006) J. Biol Chem. 281(22):15554-63 Berra E. et al., (2006) EMBO.7(1):41-5 Hussain KK, et al. Amperometric sensing of HIF1α expressed in cancer cells and the effect of hypoxic mimicking agents. (Biosens Bioelectron. 2016){https://pubmed.ncbi.nlm.nih.gov/27132006/}
NCBI	NP_001521
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Hypoxia inducible factor 1 subunit alpha,Hypoxia-inducible factor 1-alpha,HIF1-alpha,ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,bHLHe78,Member of PAS protein 1,PAS domain-containing protein 8,PASD8,MOP1
Similar products	HIF-1 alpha, HIF1A, MOP1, PASD8, bHLHe78, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Member of PAS protein 1, HIF1 alpha, ARNT interacting protein, Member of PAS superfamily 1, HIF 1alpha, HIF 1A, HIF1 A, Hypoxia inducible factor 1 alpha, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Member of the PAS Superfamily 1, MOP 1, PASD 8, HIF1 a, Hypoxia-inducible factor-1a, Hif-1 alpha (530-826 aa), Hypoxia-inducible factor 1 alpha, Hypoxia-inducible factor-1a Basic helix loop helix PAS protein MOP1, HIF0501-10ug, HIF0501-20ug, HIF0501-50ug, HIF0501-100ug, HIF0501-250ug, HIF0501-500ug, HIF0501-1mg, HIF0501-10, HIF0501-20, HIF0501-50, HIF0501-100, HIF0501-250, HIF0501-500, HIF0501-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	32.8 kDa (298aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description	Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1beta subunit and one of three subunits (Hif-1alpha, Hif-2 or Hif-3). The activation of Hif-1 is closely associated with a variety of tumors and oncogenic pathways. Hif-1alpha consists of DNA binding domain (DBD domain), Dimerization domain and C-terminla regulatiory domains, including two transactivation domains (TAD), an oxygen-dependent degradation (ODD) domain, and inhibitory domains. Hif-1 alpha (530-826 residues) contains two TAD and inhibitory domain. Recombinant Hif-1 alpha (530-826 residues) was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species	Human
Gene Category	Cell Cycle
Domain	530-826aa
Species of Protein	Human
Manufacturer - Search Terms	HIF1 a, Hypoxia-inducible factor-1a, HIF1A, MOP1, Hif-1 alpha (530-826 aa), HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, Hypoxia-inducible factor 1 alpha, Hypoxia-inducible factor-1a Basic helix loop helix PAS protein MOP1, ARNT interacting protein, bHLHe78, HIF 1A, HIF 1alpha, HIF1 A, Hypoxia inducible factor 1 alpha, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Member of PAS protein 1, Member of PAS superfamily 1, Member of the PAS Superfamily 1, MOP 1, PASD 8, PASD8, HIF0501-10ug, HIF0501-20ug, HIF0501-50ug, HIF0501-100ug, HIF0501-250ug, HIF0501-500ug, HIF0501-1mg, HIF0501-10, HIF0501-20, HIF0501-50, HIF0501-100, HIF0501-250, HIF0501-500, HIF0501-1
Manufacturer - Alternative Names	Hypoxia inducible factor 1 subunit alpha, Hypoxia-inducible factor 1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, PASD8, MOP1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 7/31/2025

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