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Anti-Human Nerve Growth Factor Receptor (NGFR) - 25 µg

Anti-Human Nerve Growth Factor Receptor (NGFR) - 25 µg

Item no.	LEIN-N194-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Ashworth, A. et al. (2006) Modern Path. 19: 307 2. Carter, BD. et al. (2004) Prog. Brain Res. 146: 25 3. Itano, T. et al. (2001) Acta Med Okayama 55: 19
NCBI	4804
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Indirect
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	NGF R
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Nerve growth factor receptor (NGFR), also known as the low-affinity receptor p75NTR is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation.1 It is also involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination.2 p75NGFR contributes to delayed neuronal death (DND) after ischemia by an apoptotic mechanism.3
Background	Nerve growth factor receptor (NGFR), also known as the low-affinity receptor p75NTR is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation.¹ It is also involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination.² p75NGFR contributes to delayed neuronal death (DND) after ischemia by an apoptotic mechanism.³
PubMed	NGF R
Manufacturer - Specificity	Goat Anti-Human Nerve Growth Factor Receptor (NGFR) recognizes Human NGFR. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831427
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human NGFR (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, NGF R, CD271, TNFRSF16, P75 (Neurotrophin Receptor) NTR, LNGFR, NGF R, Human NGF R, Anti-Human NGF R, CD271 antigen, CD271, Gp80-LNGFR, member 16, nerve growth factor receptor, NGF R, NGF receptor, NGFR, p75 ICD, p75 NTR, TNFRSF16, TNFRSF16nerve growth factor receptor TNFR superfamily, member 16, tumor necrosis factor receptor superfamily member 16

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-N194-25ug-safety-datasheet.pdf