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Anti-Human Osteoprotegerin - 25 µg

Anti-Human Osteoprotegerin - 25 µg

Item no.	LEIN-O104-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Kurihara, H. et al. (2002) Cytokine 18: 133 2. Schoppet, M. et al. (1980) Arteriosclerosis, Thrombosis, & Vascular Biol. 22: 549 3. Dunstan, CR. et al. (2001) J Bone Miner Res. 16: 348
NCBI	4982
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	Osteoprotegerin
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival.1 It is a member of the tumor necrosis factor (TNF) receptor superfamily.2 OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.3
Background	Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival.¹ It is a member of the tumor necrosis factor (TNF) receptor superfamily.² OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.³
Other Applications Reported In Literature	IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107. Neutralization: This antibody is useful for neutralization of Human OPG bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human OPG (at 0.1 ng/ml) is 0.25 - 0.7 µg/ml.
PubMed	Osteoprotegerin
Manufacturer - Specificity	Goat Anti-Human Osteoprotegerin (OPG) recognizes Human OPG. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831488
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Sf 21-Derived Recombinant Human Osteoprotegerin
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Osteoprotegerin, TNFRSF11B, Osteoclast Inhibitory Factor (OCIF), MGC29565, TR1, OCIT, OPG, Human Osteoprotegerin, Anti-Human Osteoprotegerin, OCIF, OCIFMGC29565, OPGtumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, TR1, tumor necrosis factor receptor superfamily, member 11b

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-O104-25ug-safety-datasheet.pdf