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Human Prolactin

Human Prolactin

Item no.	LEIN-P100-1.0mg
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	1 mg 10 mg 11 mg 250 mg 500 mg 5 mg
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Clone	172
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Paus, R. et al. (2012) Arch Dermatol Res. 304(2):115-8. 2. Zhu, Y. et al. (2008) Comp Biochem Physiol C Toxicol Pharmacol. 148(4):370-80. 3. Panina, S. et al. (2009) J Endocrinol. 201(1):115-28. 4. Neuwmann, ID. et al. (2009) Endocrinology. 150(4):1841-9. 5. Molitch MD., ME. (2005) Mayo Clinic Proceedings 80(8):1050-1057 6. Gout, PW. et al. (1980) Cancer Research 40:2433-36.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Endocrinology Hormones
Manufacturer - Targets	Prolactin
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Prolactin (PRL) or Luteotropic hormone (LTH) is best known as the pituitary modulator of lactation and reproduction.1 Prolactin is a multifaceted hormone that is capable of modulating hundreds of physiological processes in adult vertebrates.2 PRL promotes proliferation, survival and migration of cancer cells acting via the prolactin receptor (PRLR).3 It also modulates maternal behavior and mediates hypothalamic pituitary adrenal axis inhibition during lactation via PRL receptors in the brain.4 Prolactin also has a number of other effects including contributing to surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. It also decreases normal levels of sex hormones — estrogen in women and testosterone in men.5Prolactin is a single chain polypeptide of 199 amino acids with a molecular weight of about 24, 000 daltons. Its structure is similar to that of growth hormone and placental lactogen. The molecule is folded due to the activity of three disulfide bonds. Significant heterogeneity of the molecule has been described, thus bioassays and immunoassays can give different results due to differing glycosylation, phosphorylation, sulfation, as well as degradation. The non-glycosylated form of prolactin is the dominant form of prolactin that is secreted by the pituitary gland.Increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands of the breasts and increases the production of milk. However, the high levels of progesterone during pregnancy act directly on the breasts to stop ejection of milk. It is only when the levels of this hormone fall after childbirth that milk ejection is possible.
Background	Prolactin (PRL) or Luteotropic hormone (LTH) is best known as the pituitary modulator of lactation and reproduction.¹ Prolactin is a multifaceted hormone that is capable of modulating hundreds of physiological processes in adult vertebrates.² PRL promotes proliferation, survival and migration of cancer cells acting via the prolactin receptor (PRLR).³ It also modulates maternal behavior and mediates hypothalamic pituitary adrenal axis inhibition during lactation via PRL receptors in the brain.⁴ Prolactin also has a number of other effects including contributing to surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. It also decreases normal levels of sex hormones — estrogen in women and testosterone in men.⁵ Prolactin is a single chain polypeptide of 199 amino acids with a molecular weight of about 24, 000 daltons. Its structure is similar to that of growth hormone and placental lactogen. The molecule is folded due to the activity of three disulfide bonds. Significant heterogeneity of the molecule has been described, thus bioassays and immunoassays can give different results due to differing glycosylation, phosphorylation, sulfation, as well as degradation. The non-glycosylated form of prolactin is the dominant form of prolactin that is secreted by the pituitary gland. Increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands of the breasts and increases the production of milk. However, the high levels of progesterone during pregnancy act directly on the breasts to stop ejection of milk. It is only when the levels of this hormone fall after childbirth that milk ejection is possible.
Cross Reactivity	Paired with Leinco Prod. No. P101, Clone No. 174: Pro 100%, BhCG < 1%, ihCG < 1%, LH < 1%, FSH < 1%. Paired with Leinco Prod. No. P102, Clone No. 180: Pro 100%, BhCG < 1%, ihCG < 1%, LH < 1%, FSH < 1%.
PubMed	Prolactin
Manufacturer - Specificity	Mouse Anti-Human Prolactin (Clone 172) recognizes Human Prolactin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2737554
Concentration	≥ 5.0 mg/ml
Formulation	This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.
Immunogen	Human Prolactin
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Prolactin, Mammotropin, Luterotropic Hormone (LTH), Lutetropin, 172, PRL, Human, Anti-Human Prolactin Purified

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LEIN-P100-1.0mg-safety-datasheet.pdf