Anti-Human PKR (CT) - 0.1 mg

IHC FFPE, WB

PKR

Next Day Ambient

The interferon-inducible, double-stranded RNA (dsRNA)- dependent protein kinase PKR is a member of the eukaryotic initiatio n factor-2 alpha (eIF2-α) kinase family, possessing serine-threonine kinase activity and two dsRNA-bindingmotifs (1) that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis (2) and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity (3, 4) in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiplemechanisms, such as the inhibition of PKR by the nonstructural protein (NS1) of the influenza virus (5). More recently, PKR has been implicated in severalneurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis (6).

PKR

AB_2831554

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.