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Anti-Human Prolactin - 25 µg

Anti-Human Prolactin - 25 µg

Item no.	LEIN-P283-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Paus, R. et al. (2012) Arch Dermatol Res. 304(2):115-8. 2. Zhu, Y. et al. (2008) Comp Biochem Physiol C Toxicol Pharmacol. 148(4):370-80. 3. Panina, S. et al. (2009) J Endocrinol. 201(1):115-28. 4. Neuwmann, ID. et al. (2009) Endocrinology. 150(4):1841-9. 5. Molitch MD., ME. (2005) Mayo Clinic Proceedings 80(8):1050-1057 6. Gout, PW. et al. (1980) Cancer Research 40:2433-36.
NCBI	5617
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Cap, IHC, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	Prolactin
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Prolactin (PRL) or Luteotropic hormone (LTH) is best known as the pituitary modulator of lactation and reproduction.1 Prolactin is a multifaceted hormone that is capable of modulating hundreds of physiological processes in adult vertebrates.2 PRL promotes proliferation, survival and migration of cancer cells acting via the prolactin receptor (PRLR).3 It also modulates maternal behavior and mediates hypothalamic pituitary adrenal axis inhibition during lactation via PRL receptors in the brain.4 Prolactin also has a number of other effects including contributing to surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. It also decreases normal levels of sex hormones — estrogen in women and testosterone in men.5
Background	Prolactin (PRL) or Luteotropic hormone (LTH) is best known as the pituitary modulator of lactation and reproduction.¹ Prolactin is a multifaceted hormone that is capable of modulating hundreds of physiological processes in adult vertebrates.² PRL promotes proliferation, survival and migration of cancer cells acting via the prolactin receptor (PRLR).³ It also modulates maternal behavior and mediates hypothalamic pituitary adrenal axis inhibition during lactation via PRL receptors in the brain.⁴ Prolactin also has a number of other effects including contributing to surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. It also decreases normal levels of sex hormones — estrogen in women and testosterone in men.⁵
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human PRL bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human PRL (at 0.5 ng/ml) is 0.02 - 0.05 µg/ml. Immunohistochemistry: Suitable for use at concentration of 1-15 µg/mL.
PubMed	Prolactin
Manufacturer - Specificity	Goat Anti-Human Prolactin (PRL) recognizes Human PRL. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831579
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human PRL (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Prolactin, Mammotropin, Luterotropic Hormone (LTH), Lutetropin, PRL, Human Prolactin, Anti-Human Prolactin, PRL, Prolactin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-P283-25ug-safety-datasheet.pdf