« Back
Home /
Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1) - 0.1 mg

Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1) - 0.1 mg

Item no.	LEIN-R1235-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Burnett, PE. et al. (1998) Proc. Natl. Acad. Sci. USA 95:1432 2. Inoki, K. et al. (2005) Mol. Biol. Rev. 69:79 3. Manning, BD. (2004) J. Cell Biol. 167:399 4. Um, SH. et al. (2004) Nature 431:200
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	RPS6K1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors/1, 2 Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GBL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth.3 RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.4
Background	Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors/^{1, 2} Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GBL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth.³ RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.⁴
PubMed	RPS6K1
Manufacturer - Specificity	Rabbit Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1) recognizes Human RPS6K1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831685
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:R1240
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, RPS6K1, S6K, p70 S6 Kinase, p70-S6K, RPS6K1, Human, Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1), RPS6K1 Antibody, RSK, HU-1, RSK1, MAPKAPK1A, Ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, S6K-alpha-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

LEIN-R1235-0.1mg-safety-datasheet.pdf