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Anti-Human RANTES - 25 µg

Anti-Human RANTES - 25 µg

Item no.	LEIN-R130-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Primary
Applications	WB, IHC, ICC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Lee, SC. et al. (2004) J Neurochem. 90: 297 2. Borkowski, J. et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201 3. Geiger, H. et al. (2005) Kidney Blood Press Res 28: 48 4. Hirata, I. et al.(2009) Dig Dis Sci. 54(6):1247-52. 5. Emilie, D. et al. (1994) J Exp Med. 179: 1689
NCBI	6352
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ICC, IHC FFPE, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	RANTES
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5
Background	RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine¹ is an important mediators of the immune and inflammatory response.² It is also a potent chemoattractant for T cells ³ and eosinophils.⁴ RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.⁵
Other Applications Reported In Literature	IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 5-15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107. Neutralization: This antibody is useful for neutralization of Human RANTES bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human RANTES (at 0.01 ng/ml) is 0.1 - 0.4 µg/ml. Immunocytochemistry: Suitable for use at concentration of5-15 µg/mL.
PubMed	RANTES
Manufacturer - Specificity	Goat Anti-Human Regulated upon Activation Normal T Cell Express Sequence (RANTES) recognizes Human RANTES. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831706
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human RANTES (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, RANTES, CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228, RANTES, Human RANTES, Anti-Human RANTES, CCL5, chemokine C-C motif ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 RANTES, small inducible cytokine subfamily A Cys-Cys, member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-R130-25ug-safety-datasheet.pdf