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Anti-Human RANTES - (Clone 21445) - 25 µg

Anti-Human RANTES - (Clone 21445) - 25 µg

Item no.	LEIN-R132-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug 500 ug
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, FC, IHC
Clone	21445
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Lee, SC. et al. (2004) J Neurochem. 90: 297 2. Borkowski, J. et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201 3. Geiger, H. et al. (2005) Kidney Blood Press Res 28: 48 4. Hirata, I. et al.(2009) Dig Dis Sci. 54(6):1247-52. 5. Emilie, D. et al. (1994) J Exp Med. 179: 1689
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	CyTOF®, FC, IHC, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	RANTES
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5
Background	RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine¹ is an important mediators of the immune and inflammatory response.² It is also a potent chemoattractant for T cells ³ and eosinophils.⁴ RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.⁵
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human RANTES bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human RANTES is 0.01 µg/ml. Immunohistochemistry: Suitable for use at concentration of 8-25 µg/mL. CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
PubMed	RANTES
Manufacturer - Specificity	Mouse Anti-Human Regulated Upon Activation Normal T Cell Expressed Sequence (RANTES) (Clone 21445) recognizes an epitope on Human RANTES. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2831708
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human RANTES (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, RANTES, CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228, 21445, RANTES, Human, Anti-Human RANTES, CCL5, chemokine (C-C motif) ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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LEIN-R132-25ug-safety-datasheet.pdf