Anti-Mouse SCF (Clone 40215)

SCF

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Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor1 is a paracrine regulator of germ cell development.2 SCF has the ability to stimulate the growth of hematopoietic progenitor cells and to generate colony-forming cells (CFC) from highly enriched populations of hematopoietic cells.3 SCF is produced by the Sertoli cells and involved in the local regulation of spermatogenesis4 and liver regeneration.5 SCF in conjunction with interleukin-31 may play a significant role in airway remodeling by promoting the recruitment of bone marrow-derived fibroblast precursors into the lung with the capacity to promote lung myofibroblast differentiation.6

Neutralization: This antibody is useful for neutralization of Mouse SCF bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse SCF (at 25 ng/ml) is 5-10 µg/ml.

Rat Anti-Mouse Stem Cell Factor (SCF) (Clone 40215.11) recognizes an epitope on Mouse SCF. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody does not cross-react with rhSCF.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

E. coli-Derived Recombinant Mouse SCF