Anti-Human ST2 - 25 µg

ELISA Cap, N, WB

ST2

Next Day Ambient

ST2 belongs to the immunoglobulin superfamily and bears significant amino acid identity (~25%) to the extracellular portion of both type I and type II interleukin 1 receptors (IL-1R). Some of the intracellular residues that are required for signal transduction through the IL-1R and are conserved in the Drosophila Toll protein are also found in the membrane form of ST2. Furthermore, the gene for ST2 was mapped to mouse chromosome 1 closely linked to the il-1r locus containing both type I and type II receptor genes in support of their common ancestry.

Neutralization: This antibody is useful for neutralization of Human ST2 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human ST2 (at 5 ng/ml) is 0.2 - 1 µg/ml.

Mouse Anti-Human ST2 (Clone 97203) recognizes an epitope on Human ST2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Sf 21-Derived Recombinant Human ST2 (Accession # BAA02233)

Monoclonal Antibody, ST2, T1, IL-1 R4, 97203, Human, Anti-Human ST2/IL-1 R4, DER4, DER4ST2growth stimulation-expressed, Fit-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL33R, IL-33R, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, interleukin-1 receptor-like 1, Ly84, MGC32623, Protein ST2, ST2, ST2L, ST2V, T1, T1homolog of mouse growth stimulation-expressed