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Anti-Human TNF Receptor-Associated Factor 2 (CT) (TRAF2)

Anti-Human TNF Receptor-Associated Factor 2 (CT) (TRAF2)

Item no.	LEIN-T282-1mg
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Primary Antibodies
Type	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. van Kooten, C. et al. (2000) J. Leukoc. Biol. 67:2 2. Grech, AP. et al. (2004) Immunity 21:629 3. Davies, CC. et al. (2005) Mol. Cell. Biol. 25:980 4. Kuai, J. et al. (2003) J. Biol. Chem. 278:14363
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	TNF Receptor-Associated Factor 2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress.1 TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity.2 and are critical for NF-κB activation in mouse B lymphocytes.3 TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells.4 TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
Background	Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress.¹ TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity.² and are critical for NF-κB activation in mouse B lymphocytes.³ TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells.⁴ TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
PubMed	TNF Receptor-Associated Factor 2
Manufacturer - Specificity	Rabbit Anti-Human TNF Receptor-Associated Factor 2 (TRAF2) recognizes an epitope near the C-terminus of Human, Mouse and Rat TRAF2. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831879
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-T282-1mg-safety-datasheet.pdf