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Anti-Human TIM-1 (NT) - 0.1 mg

Anti-Human TIM-1 (NT) - 0.1 mg

Item no.	LEIN-T345-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Feigelstock, D. et al. (1998) J. Virol. 72:6621 2. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135 3. Meyers, J. H. et al. (2005) Trends Mol. Med. 11:362 4. Meyers, J. H. et al. (2005) Nat. Immunol. 6:455
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Immune Checkpoints\|Primary Monoclonal Antibodies>Infectious Diseases
Manufacturer - Targets	TIM-1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
Background	The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
PubMed	TIM-1
Manufacturer - Specificity	Rabbit Anti-Human TIM-1 recognizes an epitope near the N-terminus of Human and Mouse TIM-1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831906
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:T349
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, TIM-1, T Cell Immunoglobulin and Mucin Domain Containing Protein 1, Hepatitis A Virus Cellular Receptor 1, HAVcr-1, Kim-1, Human, Anti-Human TIM-1 (NT)

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LEIN-T345-0.1mg-safety-datasheet.pdf