Anti-Human TRAIL R4 (Clone 104918) - 500 µg

ELISA Cap, FC, N, WB

TRAIL R4

Next Day Ambient

TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1, 2

Neutralization: This antibody is useful for neutralization of Human TRAIL R4 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human TRAIL R4 (at 10 ng/ml) is 0.04 – 0.2 µg/ml.

Mouse Anti-Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4) (Clone 104918) recognizes an epitope on Human TRAIL R4. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human TRAIL R4 (> 98%)

Monoclonal Antibody, TNF-Related Apoptosis-Inducing Ligand Receptor 4, TNFRSF10D, Decoy Receptor 2 (DCR2), CD264, TRUNDD, TR4, 104918, TRAIL R4, Human, Anti-Human TRAIL R4, CD264 antigen, CD264, DcR2, DCR2decoy with truncated death domain, Decoy receptor 2, TNF receptor-related receptor for TRAIL, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4, TRAILR4, TRAIL-R4, TRAILR4TRAIL receptor 4, TRUNDDTRAIL receptor with a truncated death domain, tumor necrosis factor receptor superfamily member 10D, tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain